CBD Oil for Deep Sleep: How to Get More Slow-Wave Sleep
By PureCraft Editorial Team | PureCraft CBD | Updated October 2026
You can spend eight hours in bed and still wake up exhausted. The reason is almost never about total sleep time — it's about how much of that time is spent in deep sleep. N3 slow-wave sleep is the most physically restorative stage of the night, and most adults are chronically under-sleeping in it. CBD oil and sleep quality research increasingly focuses here: not just on falling asleep faster, but on protecting and deepening the most valuable sleep your body gets.
This guide covers what deep sleep actually is, why most people don't get enough of it, and how CBD oil interacts with the neurological systems that control slow-wave sleep — including the glymphatic system, growth hormone release, and immune activation that happen only during N3.
What Is Deep Sleep (N3 / Slow-Wave Sleep)?
Sleep isn't a single state — it cycles through four distinct stages throughout the night. N3 slow-wave sleep (SWS), also called deep sleep or delta sleep, is the third non-REM stage. It's characterized by large-amplitude, low-frequency delta brain waves (0.5–4 Hz) that reflect the most synchronized, restorative brain state achievable during sleep.
Deep sleep typically occupies 13–23% of total sleep time in healthy adults — roughly 60–110 minutes across a full night. Critically, it's front-loaded: the majority of N3 occurs in the first two sleep cycles (roughly the first three to four hours of the night), which is why the first half of your night is disproportionately important for physical restoration.
| Sleep Stage | % of Night | Brain Waves | Primary Function | When It Peaks |
|---|---|---|---|---|
| N1 (Light) | 5% | Alpha/Theta | Sleep entry transition | Sleep onset |
| N2 (Core) | ~50% | Sleep spindles/K-complexes | Memory consolidation, temperature regulation | Throughout night |
| N3 (Deep / SWS) | 13–23% | Delta (0.5–4 Hz) | Physical repair, glymphatic clearance, HGH, immune activation | First 3–4 hours |
| REM | 20–25% | Mixed/rapid eye movement | Emotional processing, memory, creativity | Final 2–3 hours |
What Happens During Deep Sleep: The Four Restorative Processes
N3 is biologically distinct from all other sleep stages. While you're in slow-wave sleep, your body is performing four critical restorative processes simultaneously — none of which can be replicated at any other time.
1. Glymphatic Brain Clearance
The glymphatic system is a brain-cleaning mechanism that becomes 60% more active during deep sleep. Cerebrospinal fluid flows through channels surrounding brain arteries, flushing out metabolic waste products that accumulate during waking hours — including amyloid-beta and tau proteins associated with cognitive decline. This glymphatic clearance is almost exclusively a deep-sleep function: poor N3 sleep over years is now recognized as a major risk factor for neurodegenerative disease. Even one night of disrupted deep sleep results in measurably elevated amyloid-beta the following morning.
2. Human Growth Hormone (HGH) Release
Approximately 70–80% of daily human growth hormone is released in a single large pulse during the first N3 episode of the night — typically within 60–90 minutes of sleep onset. HGH drives muscle protein synthesis, fat metabolism, cellular repair, and bone density maintenance. This is why the phrase "you grow while you sleep" has direct biological truth: adults who lose deep sleep see measurable declines in lean muscle mass, increased visceral fat accumulation, and slower recovery from physical stress. Shift workers and people with severe insomnia who chronically miss this first deep sleep episode show significantly altered body composition over time.
3. Immune System Activation
Deep sleep is when your immune system shifts into active mode. Pro-inflammatory cytokines — including interleukin-1 (IL-1) and tumor necrosis factor (TNF-α) — are released during N3 and drive immune surveillance, pathogen clearance, and the consolidation of immunological memory from vaccinations. This is why you sleep more when sick (your immune system is demanding deep sleep to do its job), and why chronic sleep deprivation is associated with blunted vaccine response, increased infection susceptibility, and heightened systemic inflammation.
4. Tissue Repair and Physical Restoration
Beyond HGH-driven muscle protein synthesis, deep sleep coordinates tissue-level repair throughout the body: cardiovascular system recovery (blood pressure and heart rate reach their lowest points), metabolic restoration (glucose regulation and insulin sensitivity improve), spinal disc rehydration, and bone remodeling. Athletes who optimize deep sleep show significantly faster recovery between training sessions, reduced injury rates, and better performance metrics — which is why N3 is sometimes called the "athletic performance window."
Why Deep Sleep Declines With Age
- At age 20, N3 typically occupies ~20–22% of total sleep time
- By age 40, most adults are down to 12–16% N3
- By age 60+, some individuals have <5% N3 — barely enough to support baseline restoration
- This decline is driven by reduced slow-wave activity amplitude, not shorter sleep duration
- Alcohol, cannabis with high THC, benzodiazepines, and beta-blockers all suppress N3
- Stress hormones (particularly cortisol) fragmenting the first sleep cycle destroy the most valuable deep sleep window
What Disrupts Deep Sleep
Understanding what suppresses N3 is as important as knowing how to support it. Many common habits and substances that people believe help sleep actually destroy its quality — specifically by cutting into slow-wave sleep.
| Disruptor | Effect on N3 | Mechanism | Recovery Time |
|---|---|---|---|
| Alcohol | Suppresses N3 in second half of night | Rebound arousal as alcohol metabolizes | 1–2 nights |
| Chronic stress / high cortisol | Fragments first sleep cycle; reduces delta amplitude | HPA hyperactivation disrupts sleep onset and N3 entry | Weeks of HPA recalibration |
| Benzodiazepines / Z-drugs | Severely suppress N3 | GABA-A modulation shifts architecture toward N2 | Weeks after discontinuation |
| High-THC cannabis | Suppresses N3, reduces REM | CB1 agonism disrupts natural sleep cycling | 1–3 weeks after cessation |
| Evening blue light / screens | Delays sleep onset; reduces first N3 episode | Suppresses melatonin; delays sleep pressure peak | Night-to-night |
| Irregular sleep schedule | Misaligns circadian timing; fragments N3 windows | Social jet lag disrupts Process C and S synchrony | 1–2 weeks of consistency |
| Caffeine after 2 PM | Reduces total deep sleep by 15–20% | Adenosine receptor blockade reduces homeostatic sleep pressure | Night-to-night |
How CBD Oil May Support Deep Sleep: The Mechanisms
CBD oil doesn't directly sedate you or force your brain into delta wave patterns. Instead, it works upstream — addressing the neurological and hormonal factors that prevent deep sleep from emerging naturally. CBD oil and sleep hormones research shows several converging pathways that are particularly relevant to N3 specifically.
Mechanism 1: HPA Axis Modulation — Reducing Cortisol Fragmentation
The single biggest destroyer of deep sleep is elevated evening cortisol. When cortisol remains high at bedtime — as it does in chronically stressed individuals — it prevents the smooth entry into N3 and fragments the first sleep cycle, precisely when the most important deep sleep episode should occur. CBD interacts with the hypothalamic-pituitary-adrenal (HPA) axis through 5-HT1A serotonin receptor partial agonism and direct CB1 modulation in the hippocampus, reducing HPA hyperactivation and blunting evening cortisol elevation. This effect builds over 3–4 weeks of consistent use, gradually recalibrating the stress response system that was suppressing N3 entry.
Mechanism 2: FAAH Inhibition → Anandamide Elevation
CBD inhibits fatty acid amide hydrolase (FAAH), the enzyme that breaks down anandamide — your body's endogenous cannabinoid that activates the same receptors as THC, but gently and briefly. Higher anandamide levels from FAAH inhibition are associated with reduced anxiety, reduced pain signaling, and improved sleep architecture — particularly slow-wave sleep. Critically, CBD's anandamide elevation is dose-dependent and indirect, meaning it works with your body's natural ECS rhythm rather than overriding it the way exogenous THC does, which is why CBD preserves sleep architecture while THC disrupts it.
Mechanism 3: Adenosine Pathway Support
Adenosine is the primary driver of homeostatic sleep pressure — it accumulates throughout the day and drives the biological need for deep sleep. CBD has been shown to inhibit adenosine reuptake, allowing adenosine to accumulate more effectively and strengthening the homeostatic sleep drive (Process S) that determines how deeply and quickly you enter N3. This is the opposite of caffeine's mechanism: caffeine blocks adenosine receptors, while CBD supports adenosine signaling. The implication is that CBD may make your body better at "reading" its own sleep pressure and responding with appropriate deep sleep depth.
Mechanism 4: Anti-Inflammatory and Pain Reduction
Chronic low-grade inflammation and musculoskeletal pain are among the most common hidden disruptors of deep sleep — causing microarousals that terminate N3 episodes before their full restoration can occur. CBD's anti-inflammatory action through CB2 receptor modulation and NF-κB pathway inhibition, combined with TRPV1 receptor desensitization that reduces pain signal intensity, can reduce the arousal threshold disruptions that cut deep sleep episodes short. For individuals with arthritis, back pain, exercise-induced inflammation, or chronic inflammatory conditions, this mechanism may be particularly meaningful for N3 recovery.
How These Mechanisms Converge on N3
- Reduces cortisol fragmentation → smoother entry into first N3 episode
- Elevates anandamide → improved sleep architecture, more time in deep stages
- Supports adenosine signaling → deeper homeostatic sleep pressure, stronger N3 drive
- Reduces pain/inflammation microarousals → longer uninterrupted N3 episodes
- Anxiolytic effect → reduces the hyperarousal state that blocks N3 entry — see CBD oil for anxiety and sleep
CBD Oil and Glymphatic Clearance: The Brain-Cleaning Connection
The glymphatic system's dependence on deep sleep makes it a compelling target for CBD oil research. Several pathways suggest CBD may support glymphatic function indirectly:
Reduced neuroinflammation: Neuroinflammation impairs glymphatic flow by altering the aquaporin-4 water channels that drive cerebrospinal fluid movement through brain tissue. CBD's anti-neuroinflammatory effects through CB2 receptors and PPARγ activation may support more efficient glymphatic channel function during deep sleep.
Improved N3 quality: The most direct path to better glymphatic clearance is more and better deep sleep. By addressing the upstream factors that suppress N3 — cortisol, pain, anxiety, inflammatory arousal — CBD may indirectly improve glymphatic efficiency simply by preserving more time in the stage where it operates.
Neuroprotective properties: Preclinical research suggests CBD has direct neuroprotective effects beyond the glymphatic pathway, including antioxidant activity and modulation of apoptotic signaling in neurons under metabolic stress. While this doesn't directly link to glymphatic clearance during sleep, it contributes to the overall brain health picture that adequate N3 supports.
Important Limitation to Acknowledge
Direct human research on CBD oil and glymphatic clearance is still early-stage. The mechanisms described are plausible based on CBD's known pharmacology and glymphatic biology, but CBD is not a clinically validated treatment for any neurodegenerative condition. If you have concerns about cognitive health or early-stage neurodegeneration, work with a neurologist — CBD is not a substitute for medical evaluation.
Research Overview: CBD Oil and Sleep Architecture
| Study | Population | Finding | N3 Relevance |
|---|---|---|---|
| Blessing et al., 2015 (PMID: 26341731) | Review | CBD anxiolytic effects reduce hyperarousal | HPA modulation → better N3 entry |
| Shannon et al., 2019 (PMID: 30624194) | 72 adults (anxiety + sleep) | 79.2% improved anxiety; 66.7% improved sleep at 1 month | Anxiety reduction → reduced cortisol fragmentation of N3 |
| Russo, 2016 (PMID: 28861491) | Review | ECS modulates slow-wave sleep via adenosine signaling | Direct N3 regulation via ECS/adenosine pathway |
| Crippa et al., 2011 (PMID: 20829306) | 10 adults (SAD) | CBD reduced amygdala reactivity, reduced physiological stress response | Stress response reduction → preserved first N3 episode |
| Capano et al., 2020 (PMID: 31711352) | CBD users survey | Pain relief and sleep improvement closely correlated; anti-inflammatory effect cited | Pain/inflammation reduction → fewer N3 microarousals |
Dosing CBD Oil for Deep Sleep Support
Deep sleep optimization with CBD oil requires attention to both dose and timing. Because N3 is front-loaded in the night — occurring primarily in the first 3–4 hours of sleep — CBD needs to be active and at peak concentration when that first deep sleep window opens.
| User Profile | Starting Dose | Formulation | Timing | Rationale |
|---|---|---|---|---|
| New to CBD | 15–20 mg | Nano sublingual oil | 45 min before bed | Fast onset aligned with first N3 window |
| Stress-driven sleep disruption | 25–40 mg | Nano sublingual oil | 60 min before bed | HPA modulation needs time before sleep onset |
| Chronic insomnia / poor N3 | 40–60 mg | Extended-release softgels | 60–90 min before bed | Sustained release covers full N3 window |
| Athletes / physical recovery | 30–50 mg + topical | Softgels + cream on sore areas | 60 min before bed | Systemic + local anti-inflammatory for N3 continuity |
| Age-related N3 decline (50+) | 25–40 mg CBD + CBN | CBN+CBD+melatonin gummies | 60–75 min before bed | CBN may support N3 through complementary pathways to CBD |
Dose and Deep Sleep: What the Evidence Suggests
At low to moderate doses (10–40 mg), CBD appears to be wake-promoting or neutral on sleep architecture for some individuals, while supporting sleep initiation and N3 quality for those with anxiety-driven disruption. At higher doses (100–600 mg), CBD may have more direct sedating effects, though this research is primarily from clinical anxiety and PTSD populations. Most sleep users find a useful range of 25–60 mg. Very high doses are not necessarily better for deep sleep and may actually interfere with natural sleep cycling — more is not always more.
CBN and Deep Sleep: A Complementary Approach
CBN (cannabinol) is a minor cannabinoid with more directly sedating properties than CBD. While CBD works primarily through indirect ECS modulation and anxiolytic pathways, CBN has demonstrated affinity for both CB1 receptors (mildly, about 1/10th the potency of THC) and several non-CB receptor targets that influence sleep stage distribution. Emerging evidence suggests CBN may specifically support N3 slow-wave sleep through pathways distinct from CBD's mechanisms.
The combination of CBD and CBN is increasingly popular for deep sleep because the two cannabinoids address different aspects of the problem: CBD handles the upstream stressors that prevent N3 entry (cortisol, anxiety, arousal), while CBN may directly support the delta wave activity that defines deep sleep. Together, they may allow lower individual doses of each while achieving better N3 outcomes than either alone.
Our CBD + CBN + melatonin gummies combine this dual-cannabinoid approach with melatonin's circadian signaling to address three separate deep-sleep pathways simultaneously.
PureCraft CBD Products for Deep Sleep
For Timing-Sensitive N3 Entry: Nano CBD Sublingual Oil
The first N3 episode begins roughly 60–90 minutes after sleep onset, which means CBD needs to be actively circulating before you fall asleep. Our nano CBD broad spectrum oil achieves absorption within 15–30 minutes sublingually, reaching peak concentration in the 30–60 minute window — making it the best-timed formulation for catching that critical first deep sleep episode. Hold under the tongue for 60–90 seconds before swallowing. Standard (non-nano) sublingual oils can take 60–120 minutes to peak, often too slow to protect the first N3 window.
For All-Night N3 Coverage: Extended-Release Softgels
If your concern is maintaining N3 through multiple sleep cycles — particularly the second and third deep sleep episodes that occur later in the night — our nano CBD water-soluble broad spectrum softgels offer extended-release kinetics that provide more sustained blood levels through the night's deep sleep windows. Take 60–90 minutes before bed for onset that coincides with sleep and continues through the night. Well-suited for maintenance wakers who lose N3 in the second half of the night. Learn more about CBD oil and sleep timing for the full picture.
For Deep Sleep + Circadian Support: CBD + CBN + Melatonin Gummies
For age-related N3 decline or those who struggle with both sleep onset and deep sleep depth, our CBD + CBN + D9 + melatonin gummies deliver three sleep-supportive compounds in one dose. Melatonin addresses circadian timing (signaling that it's time for sleep), CBD addresses the anxiolytic/HPA pathway, and CBN provides direct support for slow-wave sleep staging. Take 60–75 minutes before your target sleep time.
For Physical Recovery and Pain-Driven N3 Disruption: Topical + Systemic Combination
If musculoskeletal pain or post-training inflammation is fragmenting your deep sleep, combining systemic CBD with targeted topical application can address both the central pain signaling and peripheral inflammation simultaneously. Apply our nano CBD muscle and joint cream to sore areas before bed while taking a systemic formulation (sublingual oil or softgels). This combined approach covers both the local nociceptive input and the central sensitization that drive microarousals during N3.
For Whole-Plant Deep Sleep Support: Full-Spectrum Berry Gummies
Full-spectrum formulations include the full range of minor cannabinoids, terpenes, and flavonoids present in hemp — including naturally occurring CBN, CBG, and terpenes like myrcene and linalool that may have independent sleep-supportive properties. Our nano CBD full-spectrum berry gummies deliver this complete cannabinoid profile in nano-emulsified form for enhanced bioavailability. A useful option for people who've found isolated CBD insufficient, as the entourage effect of minor cannabinoids may produce deeper sleep results than CBD alone.
Deep Sleep Optimization: CBD Oil in a Complete Protocol
N3 Optimization Protocol (30-Day Structure)
Weeks 1–2: Foundation
- Start CBD oil at 20–25 mg, 60 minutes before bed nightly
- Fix wake time — same time every morning regardless of when you fell asleep
- Eliminate alcohol within 3 hours of bed
- Cut caffeine by 2 PM (adenosine clearance for deeper sleep pressure)
- Cool bedroom to 65–68°F (body temperature drop drives N3 entry)
Weeks 3–4: Deepening
- Assess response: if sleep onset is better but N3 quality still poor, increase CBD to 40 mg or switch to softgels for extended coverage
- Consider adding CBN: use CBD+CBN+melatonin gummies 3–4 nights/week on heaviest recovery needs
- Athletes: add topical cream on training days before bed
- Track subjective restoration scores each morning — improvement in these often reflects improved N3 before you can measure it otherwise
Related Articles
- CBD Oil and Sleep Quality: What the Research Shows
- CBD Oil and Sleep Schedule: Timing for Your Circadian Rhythm
- CBD Oil for Insomnia: What the Evidence Says
- CBD Oil for Anxiety and Sleep: Breaking the Cycle
- CBD Oil, Sleep Hormones, and the HPA Axis
Frequently Asked Questions
Does CBD oil actually increase deep sleep?
The research is still developing, but the evidence points toward CBD oil improving the conditions for deep sleep rather than directly increasing delta wave activity. By reducing anxiety, modulating cortisol, supporting adenosine signaling, and reducing pain-driven arousal, CBD oil appears to help the body enter and sustain N3 more effectively. Shannon et al. (2019) found sleep improvements in 66.7% of participants, and while the specific contribution to N3 wasn't isolated, improved sleep quality typically reflects improved deep sleep architecture. This is consistent with what the ECS's role in slow-wave sleep regulation would predict.
How is CBD oil different from THC for deep sleep?
CBD oil and THC have nearly opposite effects on sleep architecture despite both coming from the cannabis plant. THC suppresses both N3 slow-wave sleep and REM sleep by directly activating CB1 receptors, which disrupts natural sleep cycling. With chronic use, THC causes rebound insomnia and "REM debt" when discontinued. CBD, by contrast, doesn't directly activate CB1 receptors — it modulates the ECS more gently through indirect mechanisms. CBD appears to preserve natural sleep architecture rather than distort it. Full-spectrum hemp CBD contains only trace amounts of THC (0.3% or less) — not enough to suppress sleep stages, while potentially providing minor cannabinoid entourage benefits.
What dose of CBD oil should I take for deep sleep?
For deep sleep support specifically, most adults find a useful starting range of 25–40 mg with a nano-emulsified formulation taken 45–60 minutes before bed. The nano formulation is important for timing — standard oil's slower absorption (60–120 minutes to peak) may be too slow to protect the first N3 episode, which opens roughly 60–90 minutes after sleep onset. If you're using CBD oil for physical recovery or chronic inflammation driving sleep disruption, consider 40–60 mg with extended-release softgels for sustained night-long coverage. Start low, assess after a week, and adjust based on morning restoration scores.
Can CBD oil help with the glymphatic system during sleep?
There's plausible mechanism-level support for CBD oil benefiting glymphatic function indirectly, though direct human research is still early-stage. The glymphatic system operates primarily during N3 deep sleep, so anything that improves deep sleep quality — including CBD's cortisol modulation, adenosine support, and anti-inflammatory effects — could improve glymphatic clearance. Additionally, CBD's direct anti-neuroinflammatory effects may support the aquaporin-4 water channels that drive glymphatic flow. But it would be premature to claim CBD oil is a proven glymphatic treatment — what we can say is that protecting deep sleep through any means, including CBD support, benefits glymphatic clearance.
Does CBD oil help HGH release during deep sleep?
Indirectly, possibly. HGH release during the first N3 episode is disrupted when stress or cortisol fragments that first deep sleep period before it can fully develop. If CBD oil's HPA axis modulation leads to a smoother, more complete first N3 episode, the HGH pulse that accompanies it may be better preserved. However, CBD oil does not directly stimulate HGH secretion — that's a pituitary function triggered by sleep stage, not cannabinoid signaling. The most direct path to preserving the HGH anabolic window is protecting the first deep sleep episode from stress-driven fragmentation, which is where CBD's anxiolytic effects may have meaningful impact.
Is CBD oil good for athletes who want better deep sleep recovery?
CBD oil is potentially well-suited for athletes concerned about deep sleep recovery, for several reasons. First, exercise-induced inflammation and muscle soreness are common N3 disruptors — CBD's anti-inflammatory and analgesic properties may reduce the arousal threshold disruptions that cut deep sleep short. Second, training stress activates the HPA axis, and chronically elevated cortisol from overtraining is a known N3 suppressor — CBD's HPA modulation addresses this. Third, the HGH anabolic window during N3 is central to muscle repair, and any improvement in N3 completeness benefits recovery directly. Combining systemic CBD oil with topical application to areas of soreness before bed is a logical athlete-specific approach.
Why does deep sleep decrease with age, and can CBD oil help?
Deep sleep declines with age primarily because of reduced slow-wave activity amplitude — older brains generate lower-voltage delta waves, producing lighter versions of N3 that are less restorative. Contributing factors include higher baseline cortisol in older adults, increased pain and inflammation, reduced adenosine sensitivity, and disrupted circadian rhythms. CBD oil's mechanisms address several of these age-related N3 suppressors: HPA modulation can reduce elevated cortisol, anti-inflammatory effects can reduce pain-driven arousals, and adenosine reuptake inhibition can strengthen homeostatic sleep pressure. CBD won't reverse the underlying neurological changes driving age-related SWS decline, but it may meaningfully support the conditions for better N3 quality within what the aging brain can still generate.
What formulation of CBD oil is best for deep sleep specifically?
For deep sleep specifically, formulation choice comes down to timing and duration. For protecting the first N3 episode (which peaks in the first 3–4 hours of the night), nano sublingual oil is best — its 15–30 minute onset ensures active blood levels during the critical first deep sleep window. For all-night N3 coverage — including the second and third deep sleep episodes in later sleep cycles — extended-release softgels provide more sustained levels through the full night. For age-related deep sleep decline or those who want additional sleep-stage support, CBD + CBN + melatonin gummies combine multiple mechanisms in one dose. For physical recovery specifically, adding topical CBD cream to the systemic formulation is worth considering.
How long does CBD oil take to improve deep sleep quality?
Expect a 2–4 week timeline for meaningful deep sleep improvement with consistent CBD oil use. The most impactful mechanism — HPA axis recalibration — requires 3–4 weeks of consistent supplementation to meaningfully shift the cortisol response that fragments N3. Some individuals notice better sleep onset and reduced nighttime waking within the first week as FAAH inhibition elevates anandamide, but the deeper improvement in N3 quality typically emerges in weeks 3–4. Consistency matters more than any individual night's dose. Taking CBD oil 4–5 nights and skipping others will provide less benefit than a consistent nightly protocol at a stable dose.
Can CBD oil replace prescription sleep medications for deep sleep?
No — CBD oil should not be used as a replacement for prescribed sleep medications without consulting your doctor, and it would be misleading to suggest it can replace them in all situations. The more relevant point is that common prescription sleep aids — particularly benzodiazepines and Z-drugs like zolpidem — actually suppress N3 deep sleep while increasing total sleep time, creating a situation where you sleep longer but more shallowly. CBD oil, by contrast, appears to support natural sleep architecture without suppressing deep sleep stages. For people looking to eventually reduce reliance on sleep medications, CBD oil used alongside CBT-I (cognitive behavioral therapy for insomnia) may support that transition — but any change to prescribed medication requires medical supervision.
References
- Blessing EM, et al. Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics. 2015;12(4):825-836. PMID: 26341731
- Shannon S, et al. Cannabidiol in Anxiety and Sleep: A Large Case Series. Perm J. 2019;23:18-041. PMID: 30624194
- Russo EB. Clinical Endocannabinoid Deficiency Reconsidered. Cannabis Cannabinoid Res. 2016;1(1):154-165. PMID: 28861491
- Crippa JA, et al. Neural basis of anxiolytic effects of cannabidiol (CBD). J Psychopharmacol. 2011;25(1):121-130. PMID: 20829306
- Corroon J, Phillips JA. A Cross-Sectional Study of Cannabidiol Users. Cannabis Cannabinoid Res. 2018;3(1):152-161. PMID: 30014049
- Capano A, et al. Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients. Postgrad Med. 2020;132(1):56-61. PMID: 31711352
Medical Disclaimer
The information in this article is for educational purposes only and does not constitute medical advice. CBD oil is not intended to diagnose, treat, cure, or prevent any disease or sleep disorder, including insomnia or any condition affecting deep sleep architecture. Individual responses to CBD vary, and results are not guaranteed.
If you are experiencing chronic sleep disruption, significant fatigue, suspected sleep apnea, or any health condition affecting sleep, consult a qualified healthcare provider before starting any supplement. Do not discontinue prescribed sleep medications or other treatments without medical supervision.
PureCraft CBD products contain hemp-derived CBD with 0.3% THC or less, in compliance with federal law. These statements have not been evaluated by the Food and Drug Administration.
